A Safer Solution for Atrial Fibrillation Introduction Pulsed Field Ablation (PFA) is a new, non-thermal method for treating atrial fibrillation (AF). It uses short, high-voltage pulses to destroy heart muscle cells. Unlike traditional radiofrequency or cryoablation, PFA protects nearby tissues such as nerves, the esophagus, and blood vessels. How PFA Works PFA works by electroporation.